Solvent-Free Synthesis of Spiro[3H-indole-3,2′-thiazolidines].
✍ Scribed by Anshu Dandia; Ruby Singh; Kapil Arya
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 108 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image The solvent‐free, microwave (MW)‐assisted synthesis of a new series of 3′‐(aryl/heteroaryl)‐1‐morpholinomethyl/piperidinomethylspiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐diones has been achieved in an open vessel. Isatins 1 undergo an easy condensation with var
## Abstract magnified image Some new derivatives of spiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐dione with the heterocyclic ring such as substituted thiazole and 1,2,4‐oxadiazole attached to the indolinone ring __via__ CH~2~ linkage has been synthesized in moderate yields. The synthesis ha
## Abstract magnified image Microwave‐assisted synthesis has been found to increase both reaction rates and yields __via__ more efficient heating compared with standard thermal conduction. Dry reaction of isatins with thiosemicarbazide and their thiosemicarbazone with secondary amine on acid—washe