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Solvent-free microwave-assisted synthesis of 1H-indole-2, 3-dione derivatives

✍ Scribed by Ashish Kumar Singh; Sudhish Kumar Shukla; Ishtiaque Ahamad; M. A. Quraishi

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
66 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Microwave‐assisted synthesis has been found to increase both reaction rates and yields via more efficient heating compared with standard thermal conduction. Dry reaction of isatins with thiosemicarbazide and their thiosemicarbazone with secondary amine on acid—washed K10 in microwave oven afforded isatin‐3‐thiosemicarbazones and N‐Mannich bases in reasonably good yield. The chemical structures were confirmed by means of ^1^H NMR, IR spectral data, and elemental analysis. J. Heterocyclic Chem., 46, 571 (2009).

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Microwave-assisted, solvent-free synthes
Microwave-assisted, solvent-free synthesis of 3′-(aryl/heteroaryl)-1-morpholinomethyl/piperidinomethylspiro[3H- indole-3,2′-thiazolidine]-2,4′(1H)-diones via 3-isatinimines
✍ Manju Pandey; Dushyant Singh Raghuvanshi; Krishna Nand Singh 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 83 KB

## Abstract magnified image The solvent‐free, microwave (MW)‐assisted synthesis of a new series of 3′‐(aryl/heteroaryl)‐1‐morpholinomethyl/piperidinomethylspiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐diones has been achieved in an open vessel. Isatins 1 undergo an easy condensation with var