Solvent-free cycloaddition reaction of 3-indolylimines with chloroacetyl chloride under microwave irradiation

✍ Scribed by Anshu Dandia; Ruby Singh; Pragati Sharma

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 114 KB
• Volume: 14
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.10180

✦ Synopsis

Abstract

Solvent‐free approach is developed for the rapid synthesis of spiro[azetidine‐indoles] 6a–g on basic alumina supported potassium carbonate (K~2~CO~3~–Al~2~O~3~) from the cycloaddition reaction of indolylimines 3 and chloroacetyl chloride 4 as synthons using microwaves. The procedure neither required toxic and hazardous base nor volatile solvents. 3 was synthesized in situ by the neat reaction of indole‐2,3‐diones 1 and fluorinated anilines 2 under microwave irradiation. Solvent‐free aminoalkylation of spiro compounds 6a and 6b has been carried out under microwaves. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:468–473, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10180