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Solvent effect on the interaction of steroids with a novel methyl β-cyclodextrin polymer

✍ Scribed by K. Sreenivasan

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 275 KB
Volume: 68
Category: Article
ISSN: 0021-8995
DOI: 10.1002/(sici)1097-4628(19980613)68:11<1857::aid-app17>3.0.co;2-r

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✦ Synopsis

Methyl b-cyclodextrin was modified by coupling 2-hydroxyethyl methacrylate using hexamethylene diisocyanate as the coupling agent. The methyl b-cyclodextrin-coupled monomer was polymerized thermally using azobisisobutyronitrile as the initiator. The new polymer is insoluble in water and organic solvents. The interaction of the polymer with two typical steroids, namely, cholesterol and testosterone, in different media of varying polarities was tested. The results showed that the polymer has a higher affinity toward cholesterol and the extent of absorption of cholesterol is found to increase with the polarity of the medium. The new polymer can be optimized as a reusable absorbent for steroids, particularly for cholesterol.

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