Solvation Effects in the Grignard Reaction with Carbonyl Compounds

✍ Scribed by Meeri Sassian; Ants Tuulmets

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 166 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390021

✦ Synopsis

Abstract

Ratios of the yields of addition and reduction products for the reactions of butylmagnesium chloride with diisopropyl ketone, methyl 2‐methylpropanoate, and isopropyl 2‐methylpropanoate in toluene were determined at different THF, diethyl ether, and tert‐butyl methyl ether contents in the Grignard reagent. Replacement of the alkoxy group in the ester leads to strikingly different results for very small additions of donors. The results are discussed in terms of the solvation of the species in the reaction mixture.