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Solution Phase Synthesis of ISIS 2922 (Vitravene) by the Modified H-Phosphonate Approach.

✍ Scribed by Colin B. Reese; Hongbin Yan


Publisher
John Wiley and Sons
Year
2003
Weight
72 KB
Volume
34
Category
Article
ISSN
0931-7597

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A rapid and efficient synthesis of oligoribonucleotides on solid support is described via coupling of 5'-Q-dimethoxytrityl-2'-O-t\_butyldimethylsilyl ribonucleoside 3'-H-phosphonates