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Solution-phase synthesis of 2,6,9-trisubstituted purines

โœ Scribed by Maria T. Fiorini; Chris Abell


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
260 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A simple three-step method for the solution-phase combinatorial synthesis of 2,6,9trisubstituted purines from 2,6-dichloropmine is described. The synthesis exploits the use of resin capture to remove excess reagent used in the f'mal step.


๐Ÿ“œ SIMILAR VOLUMES


Microwave-assisted solid-phase synthesis
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In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted

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