Solution-phase synthesis of 2,6,9-trisubstituted purines
โ Scribed by Maria T. Fiorini; Chris Abell
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 260 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A simple three-step method for the solution-phase combinatorial synthesis of 2,6,9trisubstituted purines from 2,6-dichloropmine is described. The synthesis exploits the use of resin capture to remove excess reagent used in the f'mal step.
๐ SIMILAR VOLUMES
In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted
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