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Microwave-assisted solid-phase synthesis (MASS) of 2,6,9-trisubstituted purines

โœ Scribed by Richard E. Austin; John F. Okonya; Daniel R.S. Bond; Fahad Al-Obeidi

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
73 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted solid-phase synthesis (MASS) of 2,6,9-trisubstituted purines is presented.

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