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Solution phase, solid state and computational structural studies of the 2-aryl-3-bromoquinolin-4(1H)-one derivatives1

✍ Scribed by Mphahlele, Malose J.; Fernandes, Manuel A.; El-Nahas, Ahmed M.; Ottosson, Henrik; Ndlovu, Stephen M.; Sithole, Happy M.; Dladla, Bongumusa S.; De Waal, Danita


Book ID
120576410
Publisher
Royal Society of Chemistry
Year
2002
Tongue
English
Weight
136 KB
Volume
12
Category
Article
ISSN
1472-779X

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The new N-salicylideneheteroarenamines 1 -4 were prepared by reacting the biologically relevant 3hydroxy-4-pyridinecarboxaldehyde (5) with 1H-imidazol-1-amine (6), 1H-pyrazol-1-amine ( 7), 1H-1,2,4triazol-1-amine ( 8), and 1H-1,3,4-triazol-1-amine (9). Solution 1 H-, 13 C-, and 15 N-NMR were used to

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The C-3 brominated and iodinated derivatives were prepared from the corresponding 2-arylquinolin-4(1H)-ones and their NMe-4-oxo derivatives using pyridinium tribromide in acetic acid or iodine-Na 2 CO 3 mixture in THF. The results of further studies of chemical transformation of the prepared Ξ±-haloe