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Soluble Protein Oligomers as Emerging Toxins in Alzheimer′s and Other Amyloid Diseases

✍ Scribed by Sergio T. Ferreira; Marcelo N. N. Vieira; Fernanda G. De Felice

Publisher: John Wiley and Sons
Year: 2007
Weight: 11 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200745227

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve