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Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain

✍ Scribed by Christophe ERNEUX; Manuela LEMOS; Benoît VERJANS; Pierre VANDERHAEGHEN; Anne DELVAUX; Jacques E. DUMONT


Book ID
115126261
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
559 KB
Volume
181
Category
Article
ISSN
1432-1327

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Fluorinated Analogs of Ins(1,4,5)P3
✍ James F. Marecek; Glenn D. Prestwich 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 248 KB

2-Fluoro-2-deoxy-lns(1,4,5)Ps (2) and 2,2-difluoro-Z-deoxy-Ins(l,4,5)P, (3) were synthesized from protected inositol precursors. The monofluoro compound with free 3,6-hydroxyl groups underwent slow defluorination at pH 1 13, as determined by laF-NMR, while the difluoro compound was inert. Cells can