Distinct binding sites for Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in bovine parathyroid glands
โ Scribed by Peter Enyedi; Edward Brown; Gordon Williams
- Book ID
- 115762410
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 459 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0006-291X
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๐ SIMILAR VOLUMES
## Abstract PRIPโ1 was isolated as a novel inositol 1,4,5โtrisphosphate [Ins(1,4,5)P~3~] binding protein with a domain organization similar to phospholipase Cโฮด1 (PLCโฮด1) but lacking the enzymatic activity. Further studies revealed that the pleckstrin homology (PH) domain of PRIPโ1 is the region re
2-Fluoro-2-deoxy-lns(1,4,5)Ps (2) and 2,2-difluoro-Z-deoxy-Ins(l,4,5)P, (3) were synthesized from protected inositol precursors. The monofluoro compound with free 3,6-hydroxyl groups underwent slow defluorination at pH 1 13, as determined by laF-NMR, while the difluoro compound was inert. Cells can