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Solubility and dissolution rate studies of ergotamine tartrate

✍ Scribed by John R. Anderson; Ian H. Pitman

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
456 KB
Volume
69
Category
Article
ISSN
0022-3549

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✦ Synopsis

The solubility of ergotamine tartrate in aqueous solutions of tartaric acid, citric acid, hydrochloric acid, and caffeine and the dissolution rate of ergotamine tartrate in aqueous mixtures containing hydrochloric acid, caffeine, citric acid, or sodium acetate were studied. The Noyes-Whitney model of dissolution is useful for predicting the dissolution rate of ergotamine tartrate in most of the dissolution media. The relative slowness with which ergotamine chloride (a substance with low water solubility) precipitated when ergotamine tartrate was dissolved in 0.1 M HC1 resulted in the solid dissolving faster in this medium than was predicted using the Noyes-Whitney equation.

Keyphrases 0 Ergotamine tartrate-solubility and dissolution rate U Analgesics-ergotamine tartrate, solubility and dissolution rate 0 Solubility-ergotamine tartrate, various dissolution media 0 Dissolution rates-ergotamine tartrate, various dissolution media

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