Solubility and dissolution of triamcinolone acetonide
β Scribed by L. H. Block; R. N. Patel
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 407 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
## Abstract The free hydroxyl groups in triamcinolone acetonide (**1**) were protected as silyl ethers to give the bisβsilyloxy derivative **4**. Compound **4** was then hydrogenated over 5% palladium on carbon to give the Ξ^4^β3βoxo steroid **5** which was then converted to the enolβlactone **7**
The objective of this study was to compare plasma and muscle concentrations of triamcinolone acetonide (TA) in the rat by microdialysis. Microdialysis experiments were carried out at steady state in rats after an initial I.V. bolus 50 mg/kg of the phosphate ester of TA (TAP) followed by 23 mg/kg/h i
At a constant ionic strength corresponding to human urine (I c = 0.300 mol β’ dm -3 ), the solubilities of xanthine were measured as a function of ) at the temperatures T = 298.15 K and T = 310.15 K, respectively. Highly reproducible solubility and dissociation constants were obtained. Also, for the