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Solubility and dissolution of triamcinolone acetonide

✍ Scribed by L. H. Block; R. N. Patel


Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
407 KB
Volume
62
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES


Synthesis of triamcinolone acetonide-4-1
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## Abstract The free hydroxyl groups in triamcinolone acetonide (**1**) were protected as silyl ethers to give the bis‐silyloxy derivative **4**. Compound **4** was then hydrogenated over 5% palladium on carbon to give the Ξ”^4^‐3‐oxo steroid **5** which was then converted to the enol‐lactone **7**

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The objective of this study was to compare plasma and muscle concentrations of triamcinolone acetonide (TA) in the rat by microdialysis. Microdialysis experiments were carried out at steady state in rats after an initial I.V. bolus 50 mg/kg of the phosphate ester of TA (TAP) followed by 23 mg/kg/h i

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