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Aqueous solubility of 14c-triamcinolone acetonide

✍ Scribed by Charanjit Rai Behl; Lawrence H. Block; Mitchell L. Borke

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
216 KB
Volume
65
Category
Article
ISSN
0022-3549

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## Abstract The free hydroxyl groups in triamcinolone acetonide (**1**) were protected as silyl ethers to give the bis‐silyloxy derivative **4**. Compound **4** was then hydrogenated over 5% palladium on carbon to give the Ξ”^4^‐3‐oxo steroid **5** which was then converted to the enol‐lactone **7**

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The objective of this study was to compare plasma and muscle concentrations of triamcinolone acetonide (TA) in the rat by microdialysis. Microdialysis experiments were carried out at steady state in rats after an initial I.V. bolus 50 mg/kg of the phosphate ester of TA (TAP) followed by 23 mg/kg/h i