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Solid–liquid two-phase alkylation of tetraethyl methylenebisphosphonate under microwave irradiation

✍ Scribed by István Greiner; Alajos Grün; Krisztina Ludányi; György Keglevich

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
72 KB
Volume
22
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Optimum conditions for the solid–liquid phase alkylation of tetraethyl methylenebisphosphonate are dependent on the nature of the alkyl halide. The benzylation with benzyl bromide takes place efficiently in boiling acetonitrile in the presence of potassium carbonate and a phase transfer catalyst. The ethylation with ethyl iodide was best accomplished under solventless microwave conditions in the presence of cesium carbonate and in the absence of an onium salt. The analogous propylation and butylation were complicated by the formation of mixed esters. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 22:11–, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20648

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✍ György Keglevich; Alajos Grün; Zsófia Blastik; István Greiner 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract Optimum conditions for the solid–liquid phase alkylation of methylenebis(diphenylphosphine oxide) (MBDPPO) and ethyl cyanomethylphosphonate (ECMP) were explored studying the role of phase transfer catalysis and microwave (MW) irradiation, as well as the effect of the cation of the alkal