✦ LIBER ✦

Solid–liquid phase alkylation of P=O–functionalized CH acidic compounds utilizing phase transfer catalysis and microwave irradiation

✍ Scribed by György Keglevich; Alajos Grün; Zsófia Blastik; István Greiner

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 92 KB
Volume: 22
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20673

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✦ Synopsis

Abstract

Optimum conditions for the solid–liquid phase alkylation of methylenebis(diphenylphosphine oxide) (MBDPPO) and ethyl cyanomethylphosphonate (ECMP) were explored studying the role of phase transfer catalysis and microwave (MW) irradiation, as well as the effect of the cation of the alkali carbonate. It was found that the alkylation of MBDPPO may be best accomplished in acetonitrile, in the presence of a quaternary ammonium salt and Cs~2~CO~3~, while that of ECMP in the absence of catalyst and solvent using K~2~CO~3~. MW irradiation was beneficial in both cases. During the alkylation of ECMP, by‐products coming from the alcoholysis of the diethyl ester were also identified. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:174–179, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20673

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