𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid-Supported Synthesis of a Peptide β-Turn Mimetic

✍ Scribed by Golebiowski, Adam; Klopfenstein, Sean R.; Shao, Xia; Chen, Jack J.; Colson, Anny-Odile; Grieb, Arthur L.; Russell, Anne F.

Book ID
120056462
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
63 KB
Volume
2
Category
Article
ISSN
1523-7060

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Methodology for the synthesis of mimetic
Methodology for the synthesis of mimetics of peptide β-turns
✍ Michael Kahn; Barbara Chen 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 183 KB

This letter describes a scenario which provides for the stereospecific intro uction of both the amino and carboxyl termini portion of a designed B-turn mimetic. Peptides and proteins are ubiquitously distributed in nature, and play critical roles in the regulation of virtually all biological process

The design and synthesis of mimetics of
The design and synthesis of mimetics of peptide β-turns
✍ Michael Kahn; Susanne Wilke; Barbara Chen; Kagari Fujita; Yu-Hwei Lee; Michael E 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB

The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and type II beta-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I a

Solid-phase synthesis of a type II′ β-tu
Solid-phase synthesis of a type II′ β-turn peptido-mimetic library
✍ John H Grimes Jr.; Yvonne M Angell; Wayne D Kohn 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 116 KB

The solid-phase synthesis of a dipeptide derived 2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate system (IBTM) is described. The IBTM moiety is formed via a solid-phase mediated Pictet-Spengler reaction of N-terminal tryptophan and the 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-me