The design and synthesis of mimetics of peptide β-turns

✍ Scribed by Michael Kahn; Susanne Wilke; Barbara Chen; Kagari Fujita; Yu-Hwei Lee; Michael E. Johnson

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 410 KB
• Volume: 1
• Category: Article
• ISSN: 0952-3499
• DOI: 10.1002/jmr.300010205

✦ Synopsis

The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and type II beta-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I and type II turn structures. Initial computational analysis indicates that the basic ring structure will provide an excellent foundation for the development of a varieity of beta-turn mimetics.