✍ Scribed by Elena Petricci; Michela Renzulli; Marco Radi; Federico Corelli; Maurizio Botta
No coin nor oath required. For personal study only.
An original and highly efficient Oxone ® cleavage methodology for the solid-phase synthesis of substituted uracils has been developed. An example of application of this methodology to the solid-phase synthesis of uridine derivatives is also reported.
📜 SIMILAR VOLUMES
The solid phase synthesis of oxazolidinones via a novel cylisation/cleavage reaction is described. Resin bound carbamates 2, which were obtained by reaction of Wang-resin with commereiaily available isoeyanates 1, were alkylated with glycidyltosylate to the corresponding epoxides 3. Nueleophilic ope
Starting from triazene bound ortho-halo arenes on a solid support, palladium-catalyzed alkynylations and subsequent cleavage reactions under acidic conditions give rise to ortho-alkynylaryldiazonium salts, which in turn undergo cyclization to afford substituted 4-halo-and 4-hydroxycinnolines in mode
A new synthesis of macrolactones bearing a cyclopropyl ring condensed to the macrocycle is reported via a cyclization-release strategy making use of solid-phase supported stabilized sulfur ylides.