Cyclative cleavage via solid-phase supported stabilized sulfur ylides: synthesis of macrocyclic lactones

✍ Scribed by Elena La Porta; Umberto Piarulli; Francesca Cardullo; Alfredo Paio; Stefano Provera; Pierfausto Seneci; Cesare Gennari

• Book ID: 104232299
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 264 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02258-4

✦ Synopsis

A new synthesis of macrolactones bearing a cyclopropyl ring condensed to the macrocycle is reported via a cyclization-release strategy making use of solid-phase supported stabilized sulfur ylides.