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Solid-phase synthesis of the RNA fragment: rAAGAAGAAGAAGA

✍ Scribed by G. A. van der Marel; G. Wille; J. H. van Boom

Book ID: 104588438
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 634 KB
Volume: 101
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19821010703

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✦ Synopsis

Abstract

The synthesis of the tridecaribonucleotide AAGAAGAAGAAGA on a polystyrene solid support via a phosphotriester approach is described. The assemblage of the oligomer was performed by four repeated coupling reactions of the partially protected trimer AAGp(3′) with an immobilized dimer in the presence of the activating agent (2,4,6‐triisopropylbenzenesulfonyl)‐3‐nitro‐1,2,4‐triazole. Purification of the RNA fragment was easily achieved by Sephadex G50 column chromatography.

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