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Solid phase synthesis of quinazolinones

✍ Scribed by John P Mayer; George S Lewis; Michael J Curtis; Jingwen Zhang

Book ID
104258320
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
186 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Substituted 4(3H)-quinazolinones were synthesized under acidic conditions from polymer supported anthranilamide precursors and aldehyde inputs. Dehydrogenation using potassium permanganate followed by trifluoroacetic acid cleavage afforded the desired compounds in acceptable yields and purities. Additional diversity at the 3 position was realized by employing amino acid derivatized polymer support.

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