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Solid-Phase Synthesis of Pyridones and Pyridopyrazines as Peptidomimetic Scaffolds

✍ Scribed by Creighton, Christopher J.; Zapf, Christoph W.; Bu, Jane H.; Goodman, Murray


Book ID
127098927
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
70 KB
Volume
1
Category
Article
ISSN
1523-7060

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Solid-phase synthesis of a library of fu
✍ Peter W. Davis; Stephen A. Osgood; Normand HΓ©bert; Kelly G. Sprankle; Eric E. Sw πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 223 KB πŸ‘ 2 views

A combinatorial library motif has been developed based on orthogonally protected aminodiol scaffolds. Amine functionality was derivatized by commercially available electrophiles including carboxylic acids, sulfonyl chlorides, isocyanates, and aldehydes. A hydroxyl moiety was converted to a carbamate