Simultaneous Solid-Phase Synthesis of Quinoxalinone and Benzimidazole Scaffold Libraries
β Scribed by Kou, Bin-Bin; Zhang, Fa; Yang, Tian-Ming; Liu, Gang
- Book ID
- 111931502
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 165 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1520-4766
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A combinatorial library motif has been developed based on orthogonally protected aminodiol scaffolds. Amine functionality was derivatized by commercially available electrophiles including carboxylic acids, sulfonyl chlorides, isocyanates, and aldehydes. A hydroxyl moiety was converted to a carbamate
The use of pentafluoronitrobenzene as a scaffold for solid-phase synthesis of 2,4,6-substituted-3,5-difluoronitrobenzenes is described. The scaffold is amenable to the synthesis of structurally diverse combinatorial libraries. Primary and secondary amines can be introduced to the scaffold via three