Pentafluoronitrobenzene a novel scaffold
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Richard J. Holland; Ian R. Hardcastle; Andrew G. Dick; Bernard P. Nutley; Angela
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Article
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2002
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Elsevier Science
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French
⚖ 107 KB
The use of pentafluoronitrobenzene as a scaffold for solid-phase synthesis of 2,4,6-substituted-3,5-difluoronitrobenzenes is described. The scaffold is amenable to the synthesis of structurally diverse combinatorial libraries. Primary and secondary amines can be introduced to the scaffold via three