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Solid phase synthesis of peptide–siRNA conjugates containing disulfide bond unit

✍ Scribed by Wang, Xiao-Feng; Yang, Xian-Tao; Chen, Yue; Liu, Yang; Zou, Lang; Yang, Zhen-Jun; Zhang, Li-He


Book ID
120537027
Publisher
Chinese Electronic Periodical Services
Year
2013
Tongue
English
Weight
475 KB
Volume
24
Category
Article
ISSN
1001-8417

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A straightforward stepwise method for the preparation of peptide-oligonucleotide phosphorothioate conjugates, was developed, based on the highly efficient Fmoc peptide solid phase synthesis, followed by oligonucleotide phosphorothiate chain assembly. The three conjugates synthesized contained 15-or