Solid phase synthesis of peptides containing the CH2NH peptide bond isostere
β Scribed by Sasaki, Yusuke; Coy, David H.
- Book ID
- 120991064
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 237 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0196-9781
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A protocol has been kvelopedjiu rht generation qf hylroxyehyhnine peptide bond isosmes in a poipcr- sqprted synthesis. This has been used to produce the potent HlV-I Protease inhibitor JG345 rqidiy and in good yield. Protease inhibitors have outstanding potential as therapeutic agentst. Recently it
## Abstract The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the Ξ³βGluβCys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright Β© 2003 European Peptide Society and John Wiley