Solid phase synthesis of peptide aminoalkylamides development and application of new linking agents
β Scribed by G. Breipohl; J. Knolle; R. Geiger
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 166 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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The reagent pentafluorophenyl S-acetylmercaptoacetate was used to modify the N-terminus of resin-bound side-chain-protected peptides. The modification was carried out in an automated cycle in the final stage of fluorenylmethoxycarbonyl (Fmoc)/polyamide-mediated solid-phase synthesis. Side-chain depr
A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protected cystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bond formation in this kind of oligomers, which are traditionally o