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Optimised solid phase synthesis of a cystine-linked peptide-PNA chimera

✍ Scribed by Enrico Millo; Raffaele Nicolai; Sonia Scarfi’; Carlo Scapolla; Barbara Biasotti; Umberto Benatti; Gianluca Damonte

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 121 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00373-8

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✦ Synopsis

A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protected cystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bond formation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminal cysteines.

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