## Abstract Various bifunctional aminoโprotecting groups such as the phthaloyl, succinyl, and glutaryl group were investigated as potential linker molecules for attachment to solidโsupport materials. Pentaneโ1,3,5โtricarboxylic acid 1,3โanhydride (16) offered the best properties and reacted with th
Solid-Phase Synthesis of Modified Oligonucleotides
โ Scribed by Ramon Eritja
- Book ID
- 106452114
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 526 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1573-3149
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Nucleotides. Part 55. Synthesis and Application of a Novel Linker for Solid-Phase Synthesis of Modified Oligonucleotides. -New linker molecules (I)-(IV) are prepared as alternatives to start oligonucleotide syntheses on solid supports. They have the potential to modify additionally the sugar moiety
For the first time a phosphorothioate oligoribonucleotide. namely PS-Cl4. has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC14 and binds to complementary RNA strands. Various series of modified oligodeoxynucleotides hav