## Abstract For Abstract see ChemInform Abstract in Full Text.
Novel Synthesis of 2′-O-Modified Oligonucleotides by Solid Phase Fragment Condensation
✍ Scribed by Kotomi Sasaki; Takanori Kubo; Ryoji Ueki; Mayuka Yano; Yosuke Anno; Hideki Ohba; Masayuki Fujii
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 60 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Various bifunctional amino‐protecting groups such as the phthaloyl, succinyl, and glutaryl group were investigated as potential linker molecules for attachment to solid‐support materials. Pentane‐1,3,5‐tricarboxylic acid 1,3‐anhydride (16) offered the best properties and reacted with th
Nucleotides. Part 55. Synthesis and Application of a Novel Linker for Solid-Phase Synthesis of Modified Oligonucleotides. -New linker molecules (I)-(IV) are prepared as alternatives to start oligonucleotide syntheses on solid supports. They have the potential to modify additionally the sugar moiety