A versatile solid-phase methodology for the synthesis of 1,3-diamino ketone class of cysteine protease inhibitors is reported.
Solid phase synthesis of ketones from esters
β Scribed by Owen B. Wallace
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 169 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A one-pot procedure for the solid phase synthesis of ketones from the corresponding esters, via in situ formation of the N-methoxy-Nmethylamide, is described.
π SIMILAR VOLUMES
Lipase-catalyzed synthesis of sugar fatty acid esters was performed in a heterogeneous reaction system in the presence of an organic solvent serving as adjuvant. Although the sugar is almost insoluble in such a system, high conversions to the corresponding sugar esters were achieved, due to crystall
a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-a,a-disubstituted
## Abstract For Abstract see ChemInform Abstract in Full Text.