Solid-phase synthesis of 1,3-diamino ketones
β Scribed by Chakrapani Subramanyam; Shang-Poa Chang
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 158 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A versatile solid-phase methodology for the synthesis of 1,3-diamino ketone class of cysteine protease inhibitors is reported.
π SIMILAR VOLUMES
A one-pot procedure for the solid phase synthesis of ketones from the corresponding esters, via in situ formation of the N-methoxy-Nmethylamide, is described.
1,3-Oxazolidines 9 were synthesized by using a solid support. Regioselective ring opening of resin-bound epoxy ether 3 with ammonium chloride followed by nucleophilic substitution with sodium azide gave azido alcohol 7. Reduction of 7 provided 1-amino-2-alkanol 6, which was treated with various alde