𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid-phase synthesis of 1,3-diamino ketones

✍ Scribed by Chakrapani Subramanyam; Shang-Poa Chang


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
158 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis


A versatile solid-phase methodology for the synthesis of 1,3-diamino ketone class of cysteine protease inhibitors is reported.


πŸ“œ SIMILAR VOLUMES


Solid phase synthesis of ketones from es
✍ Owen B. Wallace πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 169 KB

A one-pot procedure for the solid phase synthesis of ketones from the corresponding esters, via in situ formation of the N-methoxy-Nmethylamide, is described.

Solid-phase synthesis of 1,3-oxazolidine
✍ Heong Sub Oh; Hoh-Gyu Hahn; Seung Hoon Cheon; Deok-Chan Ha πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 185 KB

1,3-Oxazolidines 9 were synthesized by using a solid support. Regioselective ring opening of resin-bound epoxy ether 3 with ammonium chloride followed by nucleophilic substitution with sodium azide gave azido alcohol 7. Reduction of 7 provided 1-amino-2-alkanol 6, which was treated with various alde