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Solid-phase synthesis of “head-to-side chain” cyclic tripeptides using allyl deprotection

✍ Scribed by C. Flouzat; F. Marguerite; F. Croizet; M. Percebois; A. Monteil; M. Combourieu

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
295 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Head-to-side-chain" cyclic tripeptides were designed as endothelin receptor antagonists. Solid phase synthesis of cyclic peptides, using an automated allyl cleavage procedure with Pd[P(Ph3)]a followed by cyclization was performed. Synthetic procedures were established on a continous-flow peptide synthesizer.

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