𝔖 Bobbio Scriptorium
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Solid phase synthesis of enantiomerically pure polyhydroxyvalerolactams

✍ Scribed by Jordi Piró; Mario Rubiralta; Ernest Giralt; Anna Diez

Book ID
104211640
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
92 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A general method for the solid phase synthesis of type 2 3,4,5-trihydroxypiperidin-2-ones is described. Amination of D-ribonolactone 4 was accomplished using a Mitsunobu reaction, and type 7 aminolactone underwent direct lactamisation upon treatment with NaOAc. For the solid phase synthesis, the aminoacid was anchored directly to a TentaGel ® resin, and the lactamisation step was concomitant with the cleavage from the resin.

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