A general method for the solid phase synthesis of type 2 3,4,5-trihydroxypiperidin-2-ones is described. Amination of D-ribonolactone 4 was accomplished using a Mitsunobu reaction, and type 7 aminolactone underwent direct lactamisation upon treatment with NaOAc. For the solid phase synthesis, the ami
Solution- and solid-phase synthesis of enantiomerically pure spiro oxindoles
β Scribed by A.K. Ganguly; N. Seah; V. Popov; C.H. Wang; R. Kuang; A.K. Saksena; B.N. Pramanik; T.M. Chan; A.T. McPhail
- Book ID
- 104252351
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 121 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
A convenient synthesis of enantiomerically pure oxindoles using a three component reaction involving 1:3 dipolar cycloaddition reaction has been achieved using solution and solid phase chemistry.
π SIMILAR VOLUMES
PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure enantiomers using solid phase synthesis techniques. Capillary electrophoresis procedures were developed for chiral separation and determination of enantiomeric purity (ee) of the e