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Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines

โœ Scribed by Jane M Berry; Philip W Howard *; David E Thurston


Book ID
108379895
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
130 KB
Volume
41
Category
Article
ISSN
0040-4039

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Efficient solid-phase synthesis of DNA-i
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The solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) imines and biologically important pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones on Wang resin using a reduction/cyclization procedure is reported.

Simple and facile reduction of azides to
โœ Ahmed Kamal; P.S.M.M. Reddy; D.Rajasekhar Reddy ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 58 KB

The reduction of aromatic azido compounds to the corresponding amines with hydriodic acid has been investigated and found to result in high yields. This reductive methodology which proceeds under non refluxing condition has been extended for the synthesis of DNA-interactive pyrrolo[2,1-c][1,4] benzo