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Efficient solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine antitumour antibiotics

✍ Scribed by Ahmed Kamal; G.Suresh Kumar Reddy; K.Laxma Reddy; Sadagopan Raghavan

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
83 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) imines and biologically important pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones on Wang resin using a reduction/cyclization procedure is reported.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: An Efficient Synthe
ChemInform Abstract: An Efficient Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine. Synthesis of the Antibiotic DC-81.
✍ Wan-Ping Hu; Jeh-Jeng Wang; Fu-Lung Lin; Yu-Chen Lin; Shinne-Ren Lin; Mei-Hui Hs πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Synthesis of pyrrolo[2,1-c][1,4]benzodia
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via azido reductive cyclization with HMDST
✍ Ahmed Kamal; B.S.Praveen Reddy; B.S.Narayan Reddy πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 198 KB

hbama:. A new facile ffmlz~ of pyrrolo [2,l-c][l,4]bonzodazepne (PBD) ring system has been achieved by reductive cyclization of the azide ~naploying hexamethyldligilathiarlΒ’ (HMDST). pment mmul~ituted PBD and the natunfl product DC-81 have also been prepmed in good overall yields