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Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via azido reductive cyclization with HMDST

✍ Scribed by Ahmed Kamal; B.S.Praveen Reddy; B.S.Narayan Reddy

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
198 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

hbama:. A new facile ffmlz~ of pyrrolo [2,l-c][l,4]bonzodazepne (PBD) ring system has been achieved by reductive cyclization of the azide ~naploying hexamethyldligilathiarlΒ’ (HMDST). pment mmul~ituted PBD and the natunfl product DC-81 have also been prepmed in good overall yields

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