Solid phase synthesis of combinatorial libraries using anhydrides as templates
โ Scribed by John Perumattam; Sarvajit Chakravarty; Glenn A. McEnroe; R. Richard Goehring; Babu Mavunkel; Sandhya Suravajjala; Whitney W. Smith; Baili Chen
- Book ID
- 110278170
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 165 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1381-1991
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๐ SIMILAR VOLUMES
The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstra
An orthogonally protected bicyclic decapeptide has been constructed and evaluated as a template for combinatorial synthesis. This template is found most useful for solution-phase combinatorial synthesis of tetrapodal libraries.
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