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Solid-Phase Synthesis of Chlorofusin Analogues

✍ Scribed by Woon, Esther C. Y.; Arcieri, Mariangela; Wilderspin, Andrew F.; Malkinson, John P.; Searcey, Mark


Book ID
126285652
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
378 KB
Volume
72
Category
Article
ISSN
0022-3263

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Syntheses of cyclosporine analogues are reported wherein the peptide couplings were achieved in solid phase. The Wang resin was used as the solid support, and the peptide couplings commenced with the residue 11 of the cyclosporine skeleton. The couplings proceeded in a stepwide manner up to the res