Solid-phase synthesis of arylalkanolamines
โ Scribed by T Srinivasan; P Gupta; B Kundu
- Book ID
- 104231224
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 59 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A straightforward synthesis of diversely substituted sulfamides is described. The reaction of sulfamoylating agent 1 with solid-phase bound amines to give polymer bound BOC substituted sulfamides is described. Further N-alkylation is achieved under Mitsunobu conditions. Simultaneous deprotection and
Substituted 4(3H)-quinazolinones were synthesized under acidic conditions from polymer supported anthranilamide precursors and aldehyde inputs. Dehydrogenation using potassium permanganate followed by trifluoroacetic acid cleavage afforded the desired compounds in acceptable yields and purities. Add
An efficient solid phase synthesis of benzimidazol-2-one-5 carboxylic acid is described. Polymer bound o-fluoronitroaromatic compound 2 was treated with an amine to give o-nitroaniline derivative 3. Reduction of 3 with SnC12 followed by cyclization with DSC gave the benzimidazolone 5. Reaction with