Solid-Phase Synthesis of a 4-Substituted γ-Lactam Library
✍ Scribed by Vergnon, Anne L.; Pottorf, Richard S.; Winters, Michael P.; Player, Mark R.
- Book ID
- 126051487
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 229 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1520-4766
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📜 SIMILAR VOLUMES
The solid-phase synthesis of several g-methyl-substituted-g-butyrolactones using a cyclisation±cleavage reaction is reported. Chemical modi®cations of polymer-bound azido (2a) and iodo alcohols (2b) were realised in order to introduce additional diversity onto the lactone structure.
The first solid-phase synthesis of 2-substituted-3-(substituted sulfanyl)-1,2,4-benzothiadiazine 1,1-dioxides has been developed. Synthesis of the title compounds was achieved as follows: (1) sulfonylation of solid-supported primary amines with 2-nitrobenzenesulfonylchlorides, (2) reduction of the n
Resin-bound cyclobutanone iminium salts, prepared on the solid-phase using the [2+2]-keteneiminium olefin cycloaddition reaction, have been transformed into a number of distinct structural classes including γ-lactams, γ-lactones, cyclobutylamines and cyclobutanols.