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Solid-phase synthesis and evaluation of libraries of substituted 4,5-dihydropyridazinones as vasodilator agents

✍ Scribed by Nicolas Gouault; Corinne A. E. Martin-Chouly; Claire Lugnier; Jean-François Cupif; Amaury Tonnelier; Frédéric Feger; Vincent Lagente; Michèle David


Book ID
111769372
Publisher
Pharmaceutical Press
Year
2004
Tongue
English
Weight
204 KB
Volume
56
Category
Article
ISSN
2042-7158

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The use of pentafluoronitrobenzene as a scaffold for solid-phase synthesis of 2,4,6-substituted-3,5-difluoronitrobenzenes is described. The scaffold is amenable to the synthesis of structurally diverse combinatorial libraries. Primary and secondary amines can be introduced to the scaffold via three