Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries
โ Scribed by Nicolaou, K. C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J.-Y.; Li, T.
- Book ID
- 118034547
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 354 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
An efficient parallel synthesis of ureas based on amino acids is described, both in solution and on solid phase, l,l'-Carbonylbisbenzotriazole 2 is used as the coupling reagent. The ureas 5 and 10 were obtained in high yield (80-100%) and purity (71-97%).
Solution-and Solid-Phase Synthesis of Combinatorial Libraries of Trisubstituted 1,3,5-Triazines. -A general synthesis of the title compounds (III) in solution becomes possible by condensation of amidines or thiouronium salts with (I). The approach can be successfully transferred to the solid phase