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Solid and solution phase combinatorial synthesis of ureas

✍ Scribed by JoséW. Nieuwenhuijzen; Paolo G.M. Conti; Harry C.J. Ottenheijm; Joannes T.M. Linders

Book ID
104259993
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
222 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient parallel synthesis of ureas based on amino acids is described, both in solution and on solid phase, l,l'-Carbonylbisbenzotriazole 2 is used as the coupling reagent. The ureas 5 and 10 were obtained in high yield (80-100%) and purity (71-97%).

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Solution phase combinatorial synthesis of arylpiperazines
✍ Luc Neuville; Jieping Zhu 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 300 KB

A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the SNAP reaction and Schottcn-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.