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Solid phase synthesis of 5-aminopyrazoles and derivatives part II

โœ Scribed by Richard D. Wilson; Stephen P. Watson; Stephen A. Richards

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
196 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A new synthesis of 5-amino pyrazoles on a solid support via in situ generation of a resin bound aldehyde nitrile is described. The synthesis is more versatile and efficient than the method that we had previously descdbed and the new route yields complementary structures.

๐Ÿ“œ SIMILAR VOLUMES

Solid phase synthesis of 5-aminopyrazole
Solid phase synthesis of 5-aminopyrazoles and derivatives
โœ Stephen P. Watson; Richard D. Wilson; Duncan B. Judd; Stephen A. Richards ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 209 KB

The development of a novel solid phase synthesis of some 5-aminopyrazoles and derivatives is described. Reaction of hydrazines with solid supported p-keto-nitrile (1) affords 5-aminopyrazoles (2) the amino group of which is readily acylated or sulphonylated. Generation of the solid supported 13-keto

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