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Solid-Phase Synthesis of 2-Amino-5-sulfanylthiazoles

✍ Scribed by Marie Grimstrup; Florencio Zaragoza

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 148 KB
Volume: 2002
Category: Article
ISSN: 1434-193X
DOI: 10.1002/1099-0690(200209)2002:17<2953::aid-ejoc2953>3.0.co;2-5

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✦ Synopsis

A solid-phase synthesis that provides easy access to 2-amino-5-sulfanylthiazoles with variable substituents at C-2, C-4, and C-5 has been developed. The key step of this synthesis is a new C-sulfanylation of resin-bound 2-aminothiazoles by mixtures of various sulfur-containing building blocks and iodine. The resulting 2-amino-5-sulfanylthiazoles were obtained in high purities and yields after cleavage from the

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