Solid-Phase Synthesis of 1,2,3,4-Tetrahydro-β-carboline-Containing Peptidomimetics
✍ Scribed by Li, Xianfeng; Zhang, Lianshan; Zhang, Wei; Hall, Steven E.; Tam, James P.
- Book ID
- 121003037
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 55 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Die Beziehungen zwischen Struktur und neuropsychotroper Wirkung bei 6 neuen 1,2,3,4‐Tetrahydro‐β‐carbolinen werden untersucht. Die aktivste Verbindung 4b hat ein pharmakologisches Profil, das dem Chlorpromazin ähnelt. Keine der Substanzen hat dopaminerge Eigenschaften.
The stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4\_tetrahydro $-carbolines has been accomplished in good yield by a two step sequence which involves Pi&et-Spengler condensation of Nb-benzyltryptophan methyl: ester with aldehydes, followed by removal of the 2-benzyl moiety from the corr